Most Americans are deficient in magnesium, a mineral critical for brain health. Magnesium is also required for chemical reactions in hundreds of other body functions. Yet, resupplying the brain with the right kind of magnesium may reverse your brain’s age by up to nine years. Yes, there are many ways to reverse brain aging, but some are easier than others.
Brain Age Reversal
https://www.inverse.com/mind-body/cognitive-decline-can-be-reversed-in-mice-what-the-new-study-means. Nearly every disease starts as chronic low-level cellular inflammation. Left unchecked, free radical damage can result in oxidative stress, and disease pathways open easily. Controlling inflammation is possible with antioxidants. Blueberries, strawberries, and spinach provide many critical antioxidants. Not all antioxidants are the same. Different molecules require an antioxidant that can match up structurally to donate electrons.
As we age, many of our cells die naturally. However, some cells refuse to go by the wayside. They are called senescent cells and can interfere with your body’s and brain’s health. Resveratrol, fisetin, and quercetin kill or rescue senescent cells. Additionally, the aging brain becomes more susceptible to another type of free radical damage.
Nature Magazine (January 20, 2021 – https://www.nature.com/articles/s41586-020-03160-0) discovered that specific types of white blood cells (microglia) in the brain are more vulnerable to inflammation from prostaglandin E2 (PGE2). As a result, a drug is being developed to short-circuit the one pathway that allows inflammation to spread via microglia.
Healthy lifestyle practices – avoiding smoking, nutritional balance, stress management, weight management, exercise, meditation, and more- can also benefit the brain’s ability to function well.
https://www.lifeextension.com/magazine/2022/12/magnesium-helps-brain-aging. The Massachusetts Institute of Technology developed a form of magnesium that rapidly improves brain health and cognition. Magnesium L-threonate studies with laboratory animals show that magnesium is quickly raised in the brain and cerebral spinal fluid. Synapses are functional connections between two nerve cells. Magnesium is a proven protector of synapses and has been shown to increase the number of synapses when dietary magnesium levels are maintained consistently.
A clinical study using magnesium L-threonate demonstrated that the brain’s age could be reversed by as much as nine years. Pre-trial testing showed the average brain age at 57.8 years for the participants. Brain-age testing yielded an average age of 68.3 years. After the magnesium L-threonate trials, the average brain age was reversed by nine years. Similar testing has been conducted with reversing ADHD and proven successful.
More on Magnesium
https://www.lifeextension.com/magazine/2016/6/unique-magnesium-compound-reverses-brain-aging#:~:text=In%20a%20new%20human%20study,connections%20and%20youthful%20brain%20plasticity. Scientists believe that magnesium might also be valuable in treating dementia and other brain disorders. Magnesium L-threonate enhances plasticity, the brain’s ability to modify or re-wire neuronal connections. Plasticity is how we develop and learn and how the brain recovers from injury.
Tangles and plaques of beta-amyloid and tau proteins characterize Alzheimer’s disease (AD). Brain synapses are impaired significantly when tangles and plaques grow and expand. As a result, brain plasticity is inhibited, and cognition begins to decline. However, animal testing with magnesium L-threonate showed little to no loss of synapses, and no cognition deterioration was observed.
Some scientists inferred that magnesium prevented and cleared beta-amyloid plaque accumulations. Eighty percent of enzymes responsible for beta-amyloid aggregation were inhibited. Given that level of performance, magnesium is now considered a good candidate for Alzheimer’s prevention and correction.
Magnesium and Brain Plasticity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182554/. Further testing with magnesium L-threonate and patients who have PTSD (post-traumatic stress disorder) showed significant results. PTSD affects the brain in fear conditioning. Certain events can trigger fear memories. This happens despite no injurious stimuli.
Time can tamp down the response. PTSD impedes brain plasticity. Magnesium L-threonate restores brain plasticity. The fear memory appears to fade more quickly in the presence of magnesium L-threonate. Researchers are considering how magnesium could benefit those with anxiety and depression – other disorders associated with fear.
Low Levels of Magnesium Are Dangerous
https://my.clevelandclinic.org/health/diseases/23264-hypomagnesemia. Hypomagnesemia is the term used to identify low levels of magnesium. Your body must have a balance of calcium, potassium, and magnesium electrolytes to perform the required daily operations of life. Some of these minerals are stored in our bones, and we rely on these electrolytes circulating in the bloodstream.
Two percent of Americans are classified as having hypomagnesemia. That level nearly doubles when hospitalized. It doubles again when a patient is in the intensive care unit (ICU). Over half of alcoholic Americans have hypomagnesemia. A quarter of diabetics are also afflicted with low magnesium levels.
Tremors, muscle spasms/cramps, abnormal eye movement, and fatigue are common symptoms. The most prevalent cause of hypomagnesemia is diet. However, poor absorption (celiac, inflammatory bowel disease, gastric bypass, and some prescription drugs) can also contribute to this condition. Left untreated, hypomagnesemia can cause seizures, hypertension, stroke, migraine headaches, attention deficit disorder, and can lead to diabetes.
Magnesium L-threonate seems to be a potential panacea for many ailments. It can be purchased easily online or at your local pharmacy. I advocate balanced nutrition from foods rather than pills. However, magnesium L-threonate is synthetic – made from magnesium and threonic acid. Greens, nuts, seeds, dry beans, and whole grains are good natural sources of magnesium which the body needs daily.
Brain plasticity will decrease with age. So possibly, including magnesium L-threonate in your daily supplements might stave off the natural cognitive decline many experiences as they get older.
Live Longer & Enjoy Life! – Red O’Laughlin – RedOLaughlin.com
Nice article Red. It’s very interesting!